Wales manager Chris Coleman has said Aaron Ramsey is ready for World Cup action and will start Saturday's crunch qualifier against Serbia.
Ramsey has just returned from a hamstring injury suffered on the opening day of the Premier League season and has not completed 90 minutes since the Euro 2016 victory over Northern Ireland.
The 25-year-old has had only 113 minutes of first-team action for Arsenal since returning from an 11-week layoff.
But Coleman stressed Ramsey's importance as Wales attempt to overtake Group D leaders Serbia, saying: "He's ready and he looks great.
"He's not played too much football for Arsenal but, of course, he's going to start the game as we sit here now.
"However long he'll last physically, we don't know. But we do know he's generally probably one of the fittest players playing football.
"Looking at the last two months, we have to see where he's at. But he'll start the game.''
Wales beat Moldova in their opening qualifier before October draws against Austria and Georgia left them two points adrift of Serbia.
"Being without him for the first three games was a blow for us,'' Coleman added. "It would be a blow for anyone, because when our games come around they are huge challenges.
"This is another and we've always got a great chance of beating anybody when we're at our strongest.
"But you have to say without Aaron Ramsey, take him out of any team and it's a loss."
Coleman said he believed Wales had shaken off the complacency that he felt crept in against Austria and Georgia.
And he said it would be a pivotal game as Serbia -- who beat Wales 6-1 and 3-0 in 2014 World Cup qualifying -- had recovered from a disastrous Euro 2016 qualifying campaign.
"We need to make a statement, because we don't play again until after Christmas so it's a long time," he said.
"They are the last team to beat us at home in a campaign game. But we've more than made up for that since, and we've moved on.''