Athletic Bilbao took the lead, but La Liga champions Atletico Madrid fought back to claim a 4-1 win thanks to a hat trick from Antoine Griezmann.
Mikel Rico opened the scoring on 17 minutes, but Griezmann headed home just after half-time to level the scores. Raul García then bagged a penalty less than 10 minutes later and Griezmann wrapped up the points to ensure Atletico kept up the pressure on leaders Real Madrid and second placed Barcelona.
Luciano Vietto scored twice as Villarreal claimed a 3-0 win over strugglers Deportivo La Coruna to keep the top four in their sights.
Jonathan dos Santos opened the scoring for the Yellow Submarine in the 10th minute before a second-half double from Vietto sealed the win.
Villarreal finished the game with 10 men after Tomas Pina was sent off in the 80th minute for a professional foul on Depor midfielder Alex Bergantinos, but it did not affect the result.
Liverpool loanee Luis Alberto scored a magnificent winner within seconds of coming on as a substitute as Malaga claimed a 2-1 comeback victory at struggling Elche.
The hosts had taken the lead in first-half injury time thanks to a disputed headed goal by David Lomban that looked to be offside, but Malaga hit back just after the break through Ignacio Camacho, and then Luis Alberto hit the winner with 13 minutes left.
The result sees Javi Gracia's side move up to seventh and go level on points with the teams in the Europa League places, while Elche stay rooted to the bottom of the table.
Struggling Granada were held to a 1-1 draw by Getafe at Los Carmenes.
Jhon Cordoba handed the hosts the lead five minutes before the break but Emiliano Velazquez struck back deep into the second half to earn Cosmin Contra's men a share of the spoils.
The point means Granada remain in danger in 18th, while a third league draw in a row moved their opponents up a spot into 12th - four points better off.