Atletico Madrid fought back for a 2-1 win at third-division side Reus in their opening match of the Copa del Rey on Tuesday.
Reus' fans burst into celebration after half an hour when Fran Carbia pressured defender Lucas Fernandez into losing the ball before he put it past goalkeeper Miguel Moya.
The hosts' lead, however, lasted only seven minutes before striker Luciano Vietto headed home Oliver Torres' pass.
Torres then provided a corner kick for Saul Niguez to head over goalkeeper Edgar Badia, who got a hand on the ball but couldn't keep it out of his net in the 63rd.
Granada suffered a shock 2-1 defeat at Segunda Division Leganes and had midfielder Ruben Perez sent off.
The Primera Liga strugglers, who are 17th in the table following only one win in the past 11 matches, fell behind to an early goal by Guillermo, the on-loan Bilboa striker producing a neat finish after the ball broke kindly in the box.
Leganes, with just one defeat in 12 outings, grew in confidence and frustrations boiled over for the visitors as Perez was shown a straight red card following a tussle with winger Ruben Pena.
The night got worse for the Granada when goalkeeper Ivan Kelava was beaten again five minutes before half-time, Omar Ramos firing the ball in with a swerving effort from the right side of the penalty area.
Granada regrouped for the second half, and netted what could be a crucial away goal with 16 minutes left.
A corner was cleared only out to the edge of the Leganes penalty area, from where midfielder Fran Rico lashed a low half-volley back through the crowd of players and into the bottom left side.
Leganes had a chance to restore their two-goal advantage when substitute Lluis Sastre was played through late on, but this time Kelava was out quickly to make a smart reaction save with his chest to leave the tie very much in the bala