Second-placed Kano Pillars will look to end their miserable away form at struggling Heartland this weekend, as they look to keep the pressure on NPFL leaders Lobi Stars.
It's being a challenging return to the top flight for rock-bottom Heartland, who have failed to win since the end of March, scoring just one in their last five games.
League leaders Lobi Stars should make light work of a struggling Sunshine Stars in Makurdi as they look to extend their three-point lead.
Stars were only minutes from earning a third away win of the season last weekend in Akure before succumbing to a late Jide Fatokun leveller.
Reigning champions Plateau United's five-game unbeaten run will face a stern test away to Katsina United, the division's second highest scorers.
Katsina have looked solid at home this term, winning all but one of their games, while the champions have being disappointing on their travels, recording six losses.
They will need their top stars, notably Tosin Omoyele and Emmanuel Odafe, to bring their scoring boots and secure a result against an inspired Katsina side.
Can Niger Tornadoes' excellent form survive the onslaught of MFM FC in Lagos?
The Minna-based side are third on the log and are the division's form team, thanks largely to their nine-game unbeaten run.
They come up against an underwhelming MFM side, who despite having drawn twice at home this season, are always a delight to watch on home turf.
They'll hope their home support can drag them into the top half of the table during the second half of the campaign.
Wikki Tourist are home to Enugu Rangers in Bauchi, as the hosts look to build on their impressive midweek draw at the home of the champions.
If the Flying Antelopes fail to address their recent scoring problems, then Wikki, who are a menacing prospect at home, could earn a result which takes them out of the relegation zone.
In other fixtures, ninth and 10th-place Rivers United and Abia Warriors clash in Port Harcourt, where a victory for either side would push them to just outside the top four.
FC Ifeanyi Ubah will hope to ease their relegation worries with a fine performance and result against minnows Go Round FC in Nnewi, and struggling Nasarawa United are favourites to count on home form against El-Kanemi Warriors.