Jefferson Savarino scored two of Real Salt Lake's five unanswered goals in a 6-2 victory over the LA Galaxy on Tuesday night.
Real Salt Lake won at the StubHub Center for the first time since March 8, 2014.
The Galaxy lost for just the sixth time in 22 matches on July 4.
RSL had a 2-1 lead at half-time after goals by Albert Rusnak and Kyle Beckerman. In the 36th minute, Rusnak was left uncovered and he took three touches to send it past Clement Diop for a 1-0 lead. Beckerman was left alone on Rusnak's corner kick in stoppage time and headed it home.
In the second half, RSL scored four goals in 19 minutes. Yura Movsisyan redirected a cross in the 62nd minute, Savarino drove in a shot from distance in the 72nd and knocked in a rebound a few minutes later, and Joao Plata capped it with an individual effort in the 80th.
The Galaxy, which is 1-5-3 at home, scored on Ashley Cole's close-range shot in the 41st minute and Bradford Jamieson's deflected shot in the 89th.
Josef Martinez scored two goals to lift the Atlanta United past the San Jose Earthquakes 4-2.
Anton Walkes scored the go-ahead off a header in the 81st minute.
Martinez scored his second goal of the match -- ninth of the season -- in the 89th minute to clinch the win.
San Jose scored in the second minute and led 1-0 at half-time, but played with 10 men after defender Kofi Sarkodie drew a red card.
Martinez scored off a header from Greg Garza's cross in the 65th minute to give Atlanta a one-goal edge. Less than a minute later, San Jose's Chris Wondolowski equalized by beating goalkeeper Kyle Reynish to a perfectly placed cross to the far post.
The lone regular-season matchup was delayed 30 minutes because of lightning.
Atlanta now leads Orlando FC by a point for fourth place in the Eastern Conference, and hands Earthquakes manager Chris Leitch his first loss. San Jose fired manager Dominic Kinnear on June 25 and promoted Leitch, who was the club's technical director.
Prior to the match, the Earthquakes confirmed that 20-year-old midfielder Matheus Silva -- currently on loan with Reno 1868 FC -- is in a critical condition after he was involved in a swimming accident in Lake Tahoe.
Kekuta Manneh scored in the 58th minute and the Columbus Crew beat Minnesota United 1-0 in the first meeting between the teams.
Columbus won for just the third time in eight matches. Minnesota lost its second straight.
Manneh scored his second goal since being traded from Vancouver on March 30. He spun his defender near the midfield circle, dribbled in space and sent in a shot from distance.
Columbus' Ola Kamara had an open shot near the corner of the 18-yard box knocked away by Bobby Shuttleworth in the 65th minute. Eight minutes later, Justin Meram sent a through ball past the Minnesota defense, but Kamara's curling shot was wide.
Meram's deflected shot in the 78th minute fell to his feet in front of the goal, but his open rebound attempt went over the crossbar. He was wide on another scoring chance two minutes later.
Minnesota's Ibson bent a free kick over the wall in the 56th, but it was pushed away by a diving Zack Steffen.
Roland Lamah had two goals, Maximiliano Urruti scored for the fourth straight game and FC Dallas beat D.C. United 4-2 to move into a tie for first in the Western Conference.
Lamah's eight MLS goals have come in his past seven matches and Urruti's career-high 11 goals this season are the most by a FC Dallas player since Jeff Cunningham in 2009.
FC Dallas scored twice in the closing minutes of the first half for a 2-1 lead. Atiba Harris headed in Victor Ulloa's corner kick in the 41st minute for his first goal of the season. Lamah tapped in a loose ball seven minutes later.
Two minutes after half-time, Urruti chased down Michael Barrios' through ball and sent a shot from a difficult angle through the legs of Travis Worra. Lamah added another goal eight minutes later on a counter-attack with Barrios.
D.C. United, without goalkeeper Bill Hamid, lost its fifth consecutive road game. Rookie Ian Harkes opened the scoring in the 30th minute with his first MLS goal. Deshorn Brown capped the scoring in the 57th with a breakaway shot.
Clint Dempsey scored two goals, Will Bruin had a goal and an assist, and the Seattle Sounders beat the Colorado Rapids 3-1.
Seattle won its first game since June 4. Colorado hosted a game on Independence Day for the 22nd straight season, going 13-4-5.
Seattle took the lead in the sixth minute. Joevin Jones dribbled alone down the left sideline and found an unmarked Dempsey near the penalty spot. Bruin made it 2-0 on another open shot in the 30th minute after his defender fell down in the box.
Dempsey scored with his left foot in the 85th minute for a 3-1 lead. Stefan Frei's goal kick was headed on by Bruin and Dempsey outraced the defense to chip Tim Howard.
Seattle midfielder Osvaldo Alonso was taken off the field on a stretcher after injuring his left knee in the 15th minute.
Alonso, the Sounders captain, appeared to injure the knee in a collision with Rapids midfielder Bismark Adjei-Boateng.
A team trainer and Dempsey tried to help him off the field, but Alonso, a four-time MLS All-Star, had to be carried on a stretcher. Nicolas Lodeiro took the captain's armband.
Dominique Badji scored for Colorado in the 78th. Marlon Hairston ran past the defense for a chipped ball, sent it across the goal and Badji redirected it home at the far post.