Hassoun Camara scored his first goal of the season to help the Montreal Impact beat winless Columbus Crew SC 2-0 on Saturday.
Camara scored with a header following Lucas Ontivero's corner kick in the 48th minute.
Kyle Bekker added a goal in the 86th minute for Montreal, whille and Eve Bush made one save for his second clean sheet of the season.
Columbus has scored just three goals in its first five games and was shut out for the second time.
Fabian Espindola and Alvaro Saborio each scored twice to help D.C. United cruise to a 4-0 win over the Vancouver Whitecaps.
D.C. opened the scoring in the 39th minute when David Ousted could not smother Chris Rolfe's shot and Espindola pounced on the loose ball.
Espindola made it 2-0 in the 54th minute after Steve Birnbaum's header following a corner hit off the crossbar and rebounded for the striker to score.
Saborio replaced Espindola in the 79th minute and the substitute scored twice in four-minute span thanks to a pair of perfectly placed through balls from Luciano Acosta.
Sporting Kansas City lost two defenders to injuries but earned a 2-0 win on the road at the New York Red Bulls.
Kevin Ellis came off shortly before halftime with a groin injury while Chance Myers had to leave the game early in the second half after tweaking his hamstring.
Benny Feilhaber scored Sporting's opener in the 17th minute with a simple finish on a counter-attack.
The visitors added a second goal on the hour mark as Dom Dwyer spun away from Chris Duvall to score from six yards following a throw-in.
It got worse for the Red Bulls four minutes later as Bradley Wright-Phillips saw his penalty saved by Tim Melia.
Sporting KC overtook FC Dallas for the lead in the Western Conference after the Texas club could only manage a 2-2 draw with the San Jose Earthquakes.
Alberto Quintero gave San Jose the lead in the fourth minute after Quincy Amarikwa's cross bounced through the box for him to fire home.
Tesho Akindele's 36th-minute penalty drew Dallas level, but Chris Wondolowski scored 10 minutes after halftime to put the Earthquakes ahead for a second time.
But the lead this time only lasted seven minutes before San Jose defender Victor Bernardez headed Fabian Castillo's cross into his own net.
Real Salt Lake remained the only unbeaten team in MLS thanks to a 1-0 win at home over the Colorado Rapids.
Joao Plata scored the only goal in the 72nd minute after a defensive miscue as Axel Sjoberg tried to volley the ball back to his goalkeeper Zac MacMath, who had already rushed off his line.
The ball went over MacMath's head and Plata walked it in for his fourth goal in the opening five games.
RSL should have had a second goal in the closing stages but Yura Movsisyan was incorrectly ruled offside.
The New England Revolution had a would-be game-winning goal chalked off for offside and settled for a 1-1 draw with visiting Toronto FC.
Kelyn Rowe gave the Revolution the lead in the 14th minute with a powerful header following Je-Vaughn Watson's long cross.
In the second half, Jozy Altidore slipped behind the Revs defense on a breakaway and laid the ball off for a streaking Sebastian Giovinco to equalize with the help of a deflection.
Referee Edvin Jurisevic waved away the Revs' penalty shouts in the 90th minute after Michael Bradley appeared to clatter into the back of Charlie Davies, and moments later Lee Nguyen scored the apparent winner but was called offside.