Juventus boss Massimiliano Allegri said "our destiny is in our hands" after his side opened a 10-point lead atop Serie A with a 2-0 win over Empoli on Saturday.
A Lukasz Skorupski own goal put Juve ahead before Alex Sandro sealed the points, leaving Juve within touching distance of their sixth straight Scudetto.
Allegri said he was pleased with the comprehensive performance after another 2-0 win over Porto in the Champions League on Wednesday.
"It wasn't an easy game, as we're in a packed fixture list and coming off a Champions League trip to Porto," Allegri told Mediaset.
"The lads did very well this evening. Empoli are, among the teams lower down the table, the side who pass it around the most and that can be frustrating.
"We stepped up a gear after the break, scored two goals and could've had more. We really regret conceding that goal against Palermo, otherwise it would've been seven straight clean sheets."
Juventus lead second-place Roma by double digits ahead of their game at Inter on Sunday night, while their title quest was further aided by Napoli's home defeat to fourth-placed Atalanta earlier on Saturday.
But Allegri warned not to count out Napoli, whom Juventus also face in the Coppa Italia semifinals next week.
"Napoli can still be in it, but the fact remains we have to focus only on ourselves and realise our destiny is in our own hands," Allegri said.
"It will be tough against Napoli in the Coppa Italia semifinal on Wednesday and we'll have to make some more changes to ensure the fitness levels are still good enough."
Leonardo Bonucci was back in Juventus' squad after Allegri dropped him against Porto following a touchline row, but the coach said their relationship was back to normal.
"There are some things a coach needs to let slide, others that he has to focus on," Allegri said. "The most important thing is to keep a cool head and make the right choices at the right time. If you let your emotions take over, it leads to mistakes.
"Bonucci came back well, put in a good performance and the case is closed. There are moments during a season when you discuss and debate things, it's just unfortunately the whole world saw us and it might've been different if it had happened in the locker room.
"We have a group of great professionals and above all great men. Between us, we managed to give the side a shake-up it needed to stay focused against Porto.
"I have five strong centre-backs and can rest them when needed."