Hull City and the FA have suspended midfielder Jake Livermore on Friday, with multiple reports citing a failed drug test as the reason behind the ban.
The Daily Telegraph and BBC reported that the results of Livermore's test after Hull's April 25 match were positive for cocaine.
The club did not reveal an official reason for Livermore's suspension, while the FA announced a failed test but did not name the player.
The Hull Daily Mail reported that Hull City officials had previously known about the allegations and were investigating before the reports went public.
A Hull statement read: "The Football Association has suspended Hull midfielder Jake Livermore.
"Following suspension by the FA the Club has subsequently suspended Jake Livermore pending further investigations to be made by the FA and our own internal disciplinary procedures.
"The Club is unable to make any further comment during this process."
The FA's statement read: "In line with its anti-doping regulations the FA can confirm it has issued a provisional suspension to a participant following a positive test for a prohibited substance. The FA will make no further comment until it has completed its investigations into this matter."
The FA allows for up to four-year bans for players who test positive for recreational drugs on match days, though they usually offer leniency to first-time offenders.
The Professional Footballers Association declined to comment but told the Hull Daily Mail that it would support Livermore.
Livermore has started all but one of Hull's Premier League games this season but is set to miss the final two matches in their fight to avoid relegation.
After spending a season on loan at the KC Stadium, Livermore joined Hull last summer in an £8 million move and signed a three-year contract with a club option for an additional year.
The 25-year-old has made one appearance for England in a friendly against Italy in 2012.
The Tigers travel to Tottenham on Saturday in the knowledge that realistically only a win will be enough to extend their survival chances into the final week of the campaign.
The FA website suggests players failing drug tests is a rare occurrence. Of 1,604 checks carried out last season, there were only four violations.
The highest profile drug-use case in the English leagues involved goalkeeper Mark Bosnich. The Australian was charged by the FA with breaching doping regulations and bringing the game into disrepute after testing positive for cocaine in December 2002.
Chelsea sacked Bosnich and although he then appealed to the Premier League, it concluded he was not unfairly dismissed. He was banned for nine months in April 2003.
West Ham's Shaun Newton received a seven-month suspension after testing positive for cocaine following an FA Cup semifinal in 2006, while Rushden & Diamonds goalkeeper Billy Turley was banned for six months and sacked by his club following a positive test for the same drug in 2004.
Rio Ferdinand, then at Manchester United, received an eight-month ban after missing a drugs test in September 2003. The player passed a test 36 hours later but was nevertheless hit with the lengthy punishment.