Gonzalo Castro bagged a brace as a rampant Borussia Dortmund put seven past Paderborn in a comfortable 7-1 DFB Pokal victory on Wednesday.
Adrian Ramos answered a Srdjan Lakic strike the 25th minute, before Castro and Shinji Kagawa added on to give the hosts a 3-1 advantage heading into the break.
In the second half, a succession of goals from Ilkay Gundogan, Castro, Lukasz Piszczek and Henrikh Mkhitaryan completed the lopsided scoreline in Dortmund.
Bayer Leverkusen won by a similar six-goal advantage in their 6-0 defeat of Viktoria Koln.
Red-hot Javier Hernandez scored a pair of goals on either side of half-time, while Julian Brandt, Karim Bellarabi, Stefan Kiessling and Vladlen Yurchenko supplied the rest as Leverkusen ran out easy winners in Koln.
Augsburg also made light work of lower-league opponents, picking up a morale-boosting 3-0 win at 2.Bundesliga leaders Freiburg.
Ji Dong-won, Alexander Esswein and Caiuby scored the goals for the side currently rooted to the foot of the Bundesliga and therefore just one position above their hosts in the overall football pyramid.
VfB Stuttgart came through a potential banana-skin tie at Carl Zeiss Jena, winning 2-0 thanks to Martin Harnik and Alexandru Maxim.
Elsewhere, Borussia Monchengladbach beat Schalke for the second time in four days, this time winning 2-0 away from home after triumphing 3-1 at home on Sunday, while Werder Bremen won the only other all-Bundesliga tie on Wednesday night, beating Cologne 1-0 thanks to Anthony Ujah's goal against his former club.
Eintracht Braunschweig from the 2.Bundesliga eased past Reutlingen 4-0 while penalties were required to separate second-division rivals Sandhausen and Heidenheim after a goalless draw, with the away team winning 4-3.
The draw for the last 16 will be held on Sunday with an equal division of eight Bundesliga and eight lower-league clubs.