Carlo Ancelotti became the first coach to win his first seven games in charge of Bayern Munich with a 3-0 victory over Hertha Berlin taking the record champions clear at the top of the Bundesliga.
Franck Ribery set them on their way in the 16th minute before two goals in four minutes from Thiago Alcantara and the returning Arjen Robben sealed a triumph which also ended Hertha's 100 percent start to the season.
Victory takes Bayern clear at the top of the table for the first time this term, with two points between them and Cologne.
Schalke were left rooted to the foot of the Bundesliga table after falling to their fourth straight defeat of the season, a 3-1 loss at home to Cologne.
Klaas-Jan Huntelaar scored the first goal of the night and Schalke's first goal of the season, beating Timo Horn after the Cologne goakeeper had just denied Eric Maxim Choupo-Moting with an excellent save in the 36th minute.
The Royal Blues' lead lasted only a handful of minutes, though, before Yuyo Osako placed his shot inside Ralf Fahrmann's right-hand post from Anthony Modeste's knock down.
Modeste put Cologne in front with just under 15 minutes remaining before Simon Zoller compounded Schalke's woes with a close-range finish, lifting the Goats up to second in the Bundesliga and leaving a beleaguered Schalke bottom with zero points from four games.
Bayer Leverkusen were left ruing a penalty miss from Charles Aranguiz as they were held to a goalless draw at home to Augsburg.
Hakan Calhanoglu tested Marwin Hitz - the busier of two excellent goalkeepers - with a free-kick from long range which the Swiss tipped over the crossbar.
Leverkusen were then given the opportunity to take the lead in the 71st minute when Kevin Volland was obstructed in the penalty area by Jeffrey Gouweleeuw and the referee pointed to the penalty spot.
Aranguiz stepped up, but he screwed his shot wide of the right-hand post, much to Augsburg's relief.
Leipzig were denied second spot in the Bundesliga as a late Borussia Monchengladbach goal saw them held to a 1-1 draw at home.
Leipzig took an early lead when Yussuf Poulsen took the ball down the right and crossed for Timo Werner, whose first touch was excellent, but it was a defensive mix-up which ultimately allowed the former Stuttgart forward to poke the ball in from close range.
The league newcomers were buoyed by their opening goal and had chances to build on it too with both Marcel Sabitzer and Marcel Halstenberg testing goalkeeper Yann Sommer.
Werder Bremen were denied their first point of the season as Pablo de Blasis headed home late on to give Mainz a 2-1 win at the Weserstadion.
Izet Hajrovic netted a 12th-minute opener for Bremen, who had caretaker coach Alexander Nouri on their bench following Viktor Skripnik's dismissal at the weekend.
The northern Germany side held onto that lead until the 87th minute, when Yunus Malli denied them victory.
Worse was to follow, though, as De Blasis headed in Gerrit Holtmann's cross to earn Mainz all three points and take them up to seventh, leaving Bremen empty-handed once again and with no points from their first four games of the season.