Chelsea goalkeeper Thibaut Courtois has not travelled with the squad to take on Manchester United at Old Trafford after picking up an ankle injury in training, according to reports.
The injury problem is not believed to be serious, and head coach Antonio Conte is reported to be hopeful that Courtois will recover in time for the FA Cup semifinal against Tottenham at Wembley next weekend.
Asked about injury concerns at a news conference on Friday, Conte had said he had "one or two situations" to check before finalising his squad selection but declined to name the players concerned.
Asmir Begovic is expected to make his first Premier League appearance of the season.
Begovic has made just six appearances for Chelsea in all competitions this season and came close to signing for Bournemouth in January, only for Conte to block the transfer when the Blues failed to acquire a replacement.
Chelsea saw their lead at the top of the Premier League cut to four points on Saturday after Tottenham thrashed Bournemouth at White Hart Lane.
Anything less than a win at United will give their London rivals renewed hope of overhauling them in the final weeks of the title race.