Henrikh Mkhitaryan scored the only goal of the game as Manchester United returned to winning form with a 1-0 victory over Tottenham Hotspur at Old Trafford.
Mkhitaryan was played through by Ander Herrara after 29 minutes and fired past Hugo Lloris to give United reward for a first half they had dominated -- but the midfielder was stretchered off after a second-half challenge by Danny Rose.
Jose Mourinho's side attacked strongly from the off, with Paul Pogba denied by Hugo Lloris early on and Zlatan Ibrahimovic seeing a low effort stopped by the Tottenham goalkeeper.
Pogba thumped a free kick against the bar in the second half, but Spurs posed more of a threat after the break and should have levelled when the unmarked Victor Wanyama completely mistimed a free header from close range.
Liverpool lost ground on leaders Chelsea as they were held to a 2-2 draw by struggling West Ham United at Anfield.
The Reds started brightly and led after only five minutes as the Hammers' defensive fragility came to the fore when Adam Lallana was given too much time to control, turn and fire into the corner.
But after a foul by Lallana on Pedro Obiang had given West Ham a free-kick 25 yards out, Dimitri Payet curled the ball past Karius, who got a touch but was unable to keep it out.
It appeared the goalkeeper could have done better, and he was beaten again when a pass through the middle took a deflection off Jordan Henderson and fell perfectly for Michail Antonio to prod home.
Within moments of the second half starting, Mane's cross was flapped at by Darren Randolph and Divock Origi stabbed home to make it 2-2 -- but Jurgen Klopp's side could not find a winner despite waves of attacking pressure.
Diego Costa's fifth goal in six games sealed a ninth consecutive Premier League win for Chelsea as West Bromwich Albion were beaten 1-0 at Stamford Bridge.
Chelsea had been frustrated by a dogged West Brom side in a game of few clear chances before Costa secured the points with a superb finish late on.
The striker robbed Gareth McAuley on the right flank before firing a fierce angled finish past the helpless Ben Foster in the visitors' goal with 76 minutes gone.
Chelsea can now contemplate breaking their Premier League record winning streak of 11 matches with games against Sunderland, Crystal Palace, Bournemouth and Stoke all still to come this month.
Southampton bounced back from the disappointment of their Europa League exit by securing a 1-0 home win against a shot-shy Middlesbrough.
The decisive moment of a scrappy game came after 53 minutes as record signing Sofiane Boufal scored his first Premier League goal with a curling effort from 20 yards after being set up by James Ward-Prowse.
The Saints could have added to their tally, with a Jay Rodriguez header from Ward-Prowse's corner being scrambled off the line and Shane Long thwarted by a fine challenge as he looked to burst clear.
Boro, whose forward Viktor Fischer had a first-half effort scrambled off the line by Fonte, offered little as the home side dominated after the break, and should have conceded a second when the stretching Rodriguez steered a Nathan Redmond cross over the top from close range.