Cambridge are sweating on the fitness of Robbie Simpson for the visit of Hartlepool.
The striker missed Tuesday's 2-1 defeat to Cheltenham with what boss Richard Money described as a "knock".
Money is still without long-term injury victim Issa Diallo (Achilles).
Harrison Dunk, Matteo Lanzoni and Luke Chadwick are all pushing for recalls after starting on the bench in midweek.
Hartlepool striker Charlie Wyke is expected to shake off illness in time for new boss Paul Murray's first game in charge.