Manchester United, Manchester City and Tottenham all face tricky away ties in the FA Cup, after the fifth round draw was conducted on Monday.
United will travel to either Huddersfield or Birmingham, who battled out a 1-1 draw at the weekend and face a replay at St Andrew's.
Meanwhile, League One leaders Wigan will hope history can repeat itself after landing a rematch with Man City in the fifth-round draw, which went as follows:
Sheffield Wednesday vs. Notts County or Swansea
West Brom vs. Southampton
Chelsea vs. Hull
Leicester vs. Sheffield United
Huddersfield or Birmingham vs. Manchester United
Millwall or Rochdale vs. Newport or Tottenham
Brighton vs. Coventry
Wigan vs. Manchester City
The DW Stadium clash will stir memories of the 2013 final when Wigan -- then sliding out of the Premier League -- snatched a stunning late winner through a Ben Watson header.
Tottenham could travel to Millwall in a repeat of last season's quarterfinal, provided both clubs win replays over Newport and Rochdale respectively.
Chelsea were given a home tie against Hull City at Stamford Bridge, while West Brom and Southampton meet in an all-Premier League clash.
New Swansea boss Carlos Carvalhal will face a quick return to his former club Sheffield Wednesday provided Swans beat League Two Notts County in a replay.