League Two side Yeovil will host Manchester United in the FA Cup for the second time in four seasons having been pitted against Jose Mourinho's men in the fourth round.
The Glovers were the lowest-ranked side in Monday night's draw and were handed a home clash with the 12-time winners, as they were in 2015 when United won 2-0 thanks to goals from Ander Herrera and Angel Di Maria.
"I don't think I could pick anyone better to go up against in the world we live in at the moment," Yeovil boss Darren Way told the club's website. "It was an extraordinary achievement to get to the fourth round and to get Manchester United is a special moment for the club.
"I want everyone to enjoy it and embrace the fantastic challenge. The players and supporters deserve it. It's going to be a magical day."
Fellow League Two side Newport will entertain Tottenham, and Exiles boss Mike Flynn told his club's official website: "I'm over the moon. I'm so excited. "It's an amazing draw and it looks like a good candidate for TV. It's going to be so important for the club's finances."
Mansfield, another club from the fourth tier, have the carrot of welcoming Pep Guardiola's Manchester City to Field Mill if they can overcome Cardiff at home in a replay.
There are guaranteed to be at least two all-Premier League ties, with Liverpool once more at home against West Brom and Southampton facing Watford at St Mary's.
Newcastle will visit either Chelsea or Norwich, while Bournemouth would end up facing West Ham on the south coast if those two clubs can overcome respective replays against Wigan and Shrewsbury.
The 1987 FA Cup winners Coventry's reward for ousting Stoke in the third round is a trip to League One outfit MK Dons with League Two high-fliers Notts County drawn at home to either Championship leaders Wolves or Premier League strugglers Swansea.
Nottingham Forest, who knocked holders Arsenal out on Sunday and announced the appointment of Aitor Karanka as their new manager on Monday, visit Hull, the side the Gunners beat in the 2014 final.
The winners of Leicester's replay with Fleetwood will travel to Peterborough, Millwall meet Rochdale and Preston travel to South Yorkshire for a date with Sheffield United.
Either Carlisle or Sheffield Wednesday will have a home match against Stevenage or Reading.
The full draw:
Liverpool vs West Brom
Peterborough vs Fleetwood or Leicester
Huddersfield vs Birmingham
Notts County vs Wolves or Swansea
Yeovil vs Manchester United
Carlisle or Sheffield Weds vs Stevenage or Reading
Cardiff or Mansfield vs Manchester City
MK Dons vs Coventry
Millwall vs Rochdale
Southampton vs Watford
Middlesbrough vs Brighton
Bournemouth or Wigan vs Shrewsbury or West Ham
Hull vs Nottingham Forest
Newport County vs Tottenham
Norwich or Chelsea vs Newcastle
Sheffield United vs Preston