Crewe fought back from 3-0 down to force an FA Cup second-round replay after a 3-3 draw at nine-man Blackburn.
Rovers raced into a 3-0 lead inside 20 minutes at Ewood Park as Dominic Samuel fired a double either side of Danny Graham's effort.
Crewe were handed a lifeline before the break when Blackburn's Rekeem Harper was shown a straight red card for a foul on Chris Porter, who picked himself up to convert the penalty.
Blackburn were reduced to nine men in the 56th minute when Elliott Bennett was sent off for a challenge on Perry Ng, and Crewe levelled through headers from Eddie Nolan and Porter in the space of three minutes.
Jimmy Spencer fired a hat trick as Mansfield won 3-0 against former boss Paul Cox's Guiseley, who also finished with nine men.
Spencer headed Mansfield into a first-half lead before Guiseley defender Darren Holden was shown a straight red for a foul on the striker five minutes before the break.
Guiseley defender Chris M'Boungou was dismissed soon after the restart for a second yellow card, and Spencer made it 2-0 a minute later before completing his hat trick from the penalty spot.
Joe Ward crashed home a late equaliser to earn National League side Woking a replay after a 1-1 home draw against League One Peterborough.
Chez Isaac's first-half penalty was saved by Posh goalkeeper Jonathan Bond before Ryan Tafazolli edged the visitors into an interval lead, but Ward levelled in the 84th minute.
Coventry ended National League side Boreham Wood's cup adventure with a 3-0 win at the Ricoh Arena.
Duckens Nazon and Marc McNulty put Coventry in control and Jordan Shipley made it 3-0 early in the second period.
Brothers Olly and Elliot Lee were on target for Luton as the League Two leaders progressed with a 5-0 win at National League side Gateshead.
Olly Lee struck just before the break, and then Dan Potts' header made it 2-0 and Elliot Lee added a third midway through the second half. Danny Hylton and Luke Berry struck stoppage-time goals for the Hatters.
Doncaster cruised through to the third round with a 3-0 home win against local rivals Scunthorpe thanks to Tommy Rowe's double and Liam Mandeville's late effort.
Isthmian League Premier Division side Leatherhead let slip an early lead to lose 3-1 at Wycombe.
Jack Midson's penalty gave Leatherhead the advantage, but Sam Saunders equalised with a superb free kick before half-time.
Craig Mackail-Smith fired Wycombe's second and Adebayo Akinfenwa headed a third in time added on after Leatherhead's Sammy Moore had been sent off for a second bookable offence.
AFC Wimbledon won an all-League One affair by beating Charlton 3-1 at Kingsmeadow.
Charlton's Karlan Ahearne-Grant cancelled out Cody McDonald's early opener for Wimbledon, but the home side regained the lead through Lyle Taylor, who added his second from the penalty spot late on.
Joss Labadie struck early in the first half and late in the second as Newport reached the third round with a 2-0 home win over Cambridge.