Uche Ikpeazu and Adam McGurk have been ruled out of Cambridge's remaining games and will therefore miss the final home fixture of the Sky Bet League Two season against Crawley.
Striker Ikpeazu required surgery on the dislocated shoulder he suffered in the defeat at Portsmouth.
And forward McGurk tore his hamstring in training on Monday, after previously having endured knee and thigh injuries this term.
Striker Barry Corr (groin) remains out.
Crawley look set to have the same squad for this match as they...