Joe Ledley is to miss Crystal Palace's FA Cup final against Manchester United later this month and is a major doubt for Wales' Euro 2016 campaign after fracturing a fibula.
Ledley, 29, suffered what was a suspected Achilles injury in Saturday's 2-1 Premier League defeat of Stoke City but Palace confirmed on Wednesday that he has a more serious problem.
Palace have confirmed Ledley will be "continually assessed over the next few weeks" in the hope of a swift recovery, but he will miss the Cup final against Manchester United at Wembley on May 21.
The club said in a short statement on their official website: "The club can confirm that midfielder Joe Ledley sustained a leg injury in the game against Stoke City on Saturday, which saw him suffer a fracture of the fibula.
"He will be continually assessed over the next few weeks by the club's medical staff."
"Ain't nobody like Joe Ledley!"
Get well soon @joe16led.https://t.co/JvZWkzWGhF- FAWales (@FAWales) May 11, 2016
However, Wales are yet to rule the midfielder out of the running for a place in their squad for next month's European Championship finals in France.
A Football Association of Wales spokesperson told BBC Sport: "As far as we are concerned he still has a chance of playing in the Euros. Obviously our cut-off point is 31 May [UEFA's deadline for final 23-man squads]."
Chris Coleman's side have a friendly against fellow Euro 2016 qualifiers Sweden on June 5, and kick off their Group B campaign against Slovakia six days later in Bordeaux.