United face Arsenal, Spurs host Swansea and Norwich at Leicester
Arsenal's trip to Manchester United is the pick of the Premier League fixtures this weekend and elsewhere, Manchester City and Liverpool contest the Capital One Cup final.
Tottenham could capitalise on City's lack of a league match when they host Swansea on Sunday while Leicester will hope to bounce back from their defeat to Arsenal when they take on relegation-threatened Norwich City.
How will the weekend's matches go? ESPN FC's club bloggers have a look at their respective matches and you can have your say by voting in the match poll.
MAN UNITED: The season is more or less over for Manchester United. There's a chance they could yet finish in the top four but with six points separating them and Manchester City, it's incredibly unlikely. It will be difficult to beat Arsenal if David De Gea doesn't regain fitness.
Prediction: Manchester United 1-2 Arsenal -- Scott Patterson
ARSENAL: Arsene Wenger's Arsenal will be fatigued after their Barcelona ordeal in midweek, as the Gunners lost 2-0 in their Champions League round of 16 first leg. They may have to settle for a point at Old Trafford.
Prediction: Manchester United 1-1 Arsenal -- James McNicholas
TOTTENHAM: Spurs have lost the last two games that immediately followed Europa League outings -- both of them at home, against Newcastle and Crystal Palace. They are also missing Mousa Dembele, while ex-Spurs man Gylfi Sigurdsson has scored five goals in seven games for Swansea. But Mauricio Pochettino's men created plenty of chances against Palace last weekend and can nick the win.
Prediction: Tottenham 1-0 Swansea -- Ben Pearce
SWANSEA: A single point from a side the Swans have never beaten in the Premier League would represent a good return, as would a first goal for new striker Alberto Paloschi.
Prediction: Tottenham 2-1 Swansea -- Max Hicks
SOUTHAMPTON: Southampton are looking to do a rare double over champions Chelsea after a memorable 3-1 triumph at Stamford Bridge earlier in the season. Goalkeeper Fraser Forster, yet to concede since his return from a long-term knee injury, is 34 minutes away from a new Premier League club record.
Prediction: Southampton 1-0 Chelsea -- Alex Crook
CHELSEA: Southampton don't concede goals while Chelsea have suddenly rediscovered where the back of the net is. There is a confident swagger about Guus Hiddink's side that is hard to ignore right now, and the combined efforts of a re-unified Blues team should be enough to breach the Saints' net although a goal-fest seems unlikely.
Prediction: Southampton 0-1 Chelsea -- Mark Worrall
LEICESTER: Claudio Ranieri's men have had a long time to ponder their agonising 2-1 loss to Arsenal last time out and will look to put things right against struggling Norwich. Ranieri has claimed this one will be harder than a trip to the Emirates but three points shouldn't be a problem against the Canaries.
Prediction: Leicester 3-0 Norwich -- Ben Jacobs
NORWICH: Alex Neil's side must look to cash in on any lingering hangover from Leicester City's stoppage time defeat at Premier League title rivals Arsenal. The Canaries are fresh from a Middle East training break and seeking a first win since Jan. 2.
Prediction: Leicester 2-1 Norwich -- Paddy Davitt
WEST HAM: The return of Sam Allardyce to Upton Park has added a bit of spice to an otherwise mundane fixture. Expect the fans to be at their most vociferous and Big Sam to smile knowingly as he thwarts his old club.
Prediction: West Ham 1-1 Sunderland-- Peter Thorne
SUNDERLAND: The heartening 2-1 defeat of Manchester United boosted survival hopes. If Dimitri Payet's threat is neutralised, and new boys Lamine Kone and Wahbi Khazri shine again to counter West Ham's overall efficiency, manager Allardyce and striker Jermain Defoe might manage a happy Upton Park return.
Prediction: West Ham 1-2 Sunderland -- Colin Randall
STOKE: There is little excuse not to come away with all three points against a battered and bruised Aston Villa side. The potential return of Ryan Shawcross to an ailing backline and Marko Arnautovic to a misfiring attack should provide a significant boost to the Potters' chances of doing exactly that.
Prediction: Stoke 2-0 Aston Villa -- James Whittaker
ASTON VILLA: Villa need a positive reaction after the 6-0 debacle against Liverpool. Remi Garde wants to shake his team up though his options are limited. Villa have won two out of the last three league games at the Britannia but Stoke lie just four points from a top six place.
Prediction: Stoke 2-0 Aston Villa -- Kevin Hughes
WATFORD: The final day of last season is all but forgotten now, but it was a very anti-climatic moment when Watford surrendered the Championship title to Bournemouth in the last minute. There is little pressure on Watford so this is a good chance to build momentum and plunge Bournemouth back into a relegation battle.
Prediction: Watford 2-1 Bournemouth -- Michael Moruzzi
BOURNEMOUTH: With no wins in their last three matches, Bournemouth need a positive result from the game against Watford. After the FA Cup defeat at home to Everton, a number of regular league starters are expected to return at Vicarage Road. Harry Arter will be the most influential.
Prediction: Watford 1-1 Bournemouth -- Steve Menary
WEST BROM: The Baggies will want to gain some momentum in their stuttering season with a win over Tony Pulis' former side Crystal Palace. Chris Brunt will be guaranteed a good reception after last week's events and he will be crucial in shutting down Palace's biggest attacking threat, Wilfried Zaha
Prediction: West Brom 1-1 Crystal Palace -- Matthew Evans
CRYSTAL PALACE: It feels like the spark might be back for Palace after a fine FA Cup win at Tottenham. With Yannick Bolasie back and the defence finally keeping a clean sheet, things could be turning around.
Prediction: West Brom 0-1 Crystal Palace -- Jim Daly