Albert Soler and Raul Sanllehi will leave their roles with the Barcelona first team, sources have told ESPN FC.
Soler and Sanllehi have been two of the club's chief negotiators in the transfer market over recent years.
In his role as director of football, Sanllehi has been a key player in South America and was instrumental in the deal that saw Neymar join Barca in 2013.
However, a mutual agreement has been reached for him to leave on Dec. 1, with Diario Sport reporting that Manchester City and Arsenal are interested in his services.
Soler will remain at Camp Nou but his role as director of professional sports will be diluted as he takes a step away from dealing with the Barca football teams.
He has cited personal reasons for the change, which means he will focus on the basketball and handball teams.
President Josep Maria Bartomeu's plan to restructure behind the scenes has accelerated in recent days following the resignations of Carles Vilarrubi and Jordi Mones.
Vice president Vilarrubi and director Mones were against Barca's game with Las Palmas being played on the day of Catalonia's unilateral independence referendum and decided to resign following the decision to play it behind closed doors.
Bartomeu has yet to replace Susana Monje, who resigned from her role as economic vice president at the end of 2016, with CEO Oscar Grau having covered the position in the meantime.
The announcement of a complete reshuffle is expected after the club's General Assembly on Oct. 21.
Pep Segura has already been confirmed as the new general manager, a role that will see him take on a number of responsibilities that had been covered by Soler and Sanllehi.
Sporting director Robert Fernandez will continue to work alongside him.
Elsewhere, Bartomeu is expected to bring in some outside faces as vice presidents following the departures of Monje and Villarubi.
Sport reported that the Barca chief is keen to add more women to his staff, with vice secretary Maria Teixidor the only woman currently on the board.