Jack Wilshere has been ruled out of action for three months after having surgery on his ankle, Arsenal have confirmed.
Wilshere, 22, sustained damage to ligaments in his left ankle during Saturday's 2-1 defeat to Manchester United when he was tackled by defender Paddy McNair, and missed the Gunners' 2-0 Champions League win over Borussia Dortmund on Wednesday.
In a statement, Arsenal said the operation had been "successful" and added: "Jack will now commence his injury rehabilitation programme with the Arsenal medical team.
"Everyone at the club wishes Jack a speedy recovery and looks forward to seeing him back on the pitch as soon as possible."
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Among the matches Wilshere will miss are key Premier League trips to Liverpool (Dec. 21), Manchester City (Jan. 18) and Tottenham (Feb. 7), as well as the first leg of the Gunners' last-16 tie in the Champions League and several rounds of the FA Cup.
Goalkeeping duo Wojciech Szczesny and David Ospina, defender Mathieu Debuchy, attacking midfielder pair Mesut Ozil and Theo Walcott and striker Danny Welbeck were all already sidelined for the Dortmund game.
Arsenal's injury woes worsened when midfielder Mikel Arteta came off with a calf problem that manager Arsene Wenger described as "quite serious," while striker Yaya Sanogo was also brought off after scoring his first competitive goal for the club.